澳洲塔斯马尼亚论文代写:保罗

Keywords:塔斯马尼亚论文代写

保罗等人最近关于复制转录冲突的一项研究澄清了一个尚未解决的进化问题：即单个基因的进化速率如何被控制。作者认为，枯草芽孢杆菌控制的突变和进化率，通过共同的方向和正面方向与复制。

DNA复制机器位于基因的方向上，既可以面对转录机制，也可以面向同一方向或同一方向.。在滞后链上的基因是在正面方向的复制，而主导链基因是共同的方向。有证据表明，迎面交锋是更有害的比面向合作的遭遇和大多数的基因，特别是必要的基因，显示同向偏置。最近的研究都集中在冲突的发生，避免和解决机制。即使同一方向的正面冲突有了一定的差异，他们的目的是阐明积极selection2有限定向冲突的重要性。这里，保罗等人。提供了一个新的思路，正面冲突可以提高进化率根据积极选择。

澳洲塔斯马尼亚论文代写:保罗

A recent study, by Paul et al.1, about replication-transcription conflict clarified an unsolved evolutionary problem: that is, how evolution rates in individual genes are controlled. The authors responded that Bacillus subtilis controlled mutagenesis and evolution rates through co-orientation and head-on orientation with replication.
Lying on the orientation of a gene, DNA replication machinery can face transcription machinery in either head-on orientation or co-orientation. The genes on the lagging strand are in the head-on orientation to the replication, while leading-strand genes are co-directional. Evidences have shown that head-on encounters are more detrimental than co-oriented encounters and majority of genes, especially essential genes, display co-directional bias. Recent studies are focusing on mechanisms of occurrence, avoidance and resolution of conflicts. Even though the differences between co-directional and head-on conflicts have been investigated to some extent, they aimed to elucidate the importance of co-directional conflicts in positive selection2. Here, Paul et al. provides a new train of thought that head-on conflicts may improve the rates of evolution according to positive selection.